Wednesday, December 10, 2008
Back on the streets
Wednesday, November 19, 2008
The world's first camelid cDNA library
When some scholar desperate for a PhD topic turns his gaze to the history of research on camels, October 25, 2008 will undoubtedly mark a new chapter in his exceedingly tedious and irrelevant dissertation. After a year of research, the Camel Health Unit successfully synthesized the first camel-related cDNA.
DNA, being the stuff of heredity, is safely ensconced inside the cell nucleus. While this isolation ensures its integrity, it also makes DNA kind of useless. In order to get something done, the cell must transcribe instructions (genes) from DNA into RNA, which then passes out of the nucleus to be translated into proteins. These proteins are what actually do things in the cell. So if you want to study how genes get expressed rather than just how they get passed on, RNA is of far more interest, because it reflects exactly which instructions are being carried out when. But DNA is easier to study, so we collect the active RNA, copy it back into DNA, and call it cDNA.
Once you have cDNA, you can do all sorts of cool and godlike things. We're looking at the parasite Haemonchus contortus, a worm living in the camel digestive tract that feeds by digesting hemoglobin. We isolated the H. contortus RNA that codes for the protein responsible for digestion and copied it back into cDNA. Next, we'll insert that cDNA gene into the genome of a small bacteria (called a vector) and see if the genetically modified bacteria can digest hemoglobin. We'll then use that bacteria to design a simple diagnostic that would detect the presence of the hemoglobin-digesting protein in camel blood.
An interesting sidenote: even this advanced work has at its root the same large-level changes I've seen throughout Rajasthan. Desertification and overpopulation have led to a reduction in the quality topfeed (trees, tall shrubs) that camels prefer, forcing them to compete with sheep, goats, and cows for low-level grazing. This means that H. contortus, usually only found in sheep here, has moved to camels as the animals are exposed to feces-covered groundfeed.
Reasons to shave, vol. III
Whistlin down the road
Tuesday, November 18, 2008
History of camel: domestication
Every person who has argued over the relative merits of dogs versus cats as house pets has engaged the fundamental question of domestication: how do you get an animal to acknowledge your superiority? For some species, like sheep and goats, a herd mentality makes domestication the simple process of acclimatization. For others, like dogs, a hierarchical social structure means that establishing control is more of a play for dominance. And for some, like cats, the process is never fully complete, instead constituting a regular exchange of services.
Camels, despite their tendency to herd, are quite socially shrewd, so domestication involves the establishment of dominance and control. The first domesticators were probably fishermen on the coast of Yemen and Oman, who turned to the camel for milk around 2000BCE. They had no need to ride the animals, their semi-sedentary communities simply serving as a base for fishing expeditions, nor did they require the meat. Corralling a few females would have been easy-- getting one to let you touch its udder would have been the tough part.
As described earlier, the practice of keeping camels for milk is today only prevalent in Somalia and East Africa. The Arabian fishermen slowly turned their seafaring chops to trade, spreading the camel across the Red Sea. There, in one of the most inhospitable environments on earth, the camel could provide milk from land that was previously useless. The custom stuck, and even today Somalia is the home to the most camels of any country.
Me and those dreaming eyes of mine

Pushkar Unt Mela
Sunday, November 16, 2008
November
Thursday, November 13, 2008
Hipness, it is what it is
Sunday, November 9, 2008
History of camel: dominance and collapse
If the camel's close relationship to man was foreshadowed by the two species' concurrent, countercurrent, then the camel's fate during and after the last Ice Age was a sure signal of things to come.
By the middle Pleistocene, Camellus included at least seven different species spread across southern Europe, North and East Africa, the Middle East, and most of Asia. Although each differed in morphology and environment, osteological and ecological clues tell us that, by and large, they lived much as camels do today. Their adaptations to aridity gave them access to untapped resources and protected them from most predators. But periodic ice ages drove declines in the marginal areas the camels enjoyed most, pushing them into closer contact and competition with other herd animals. Humans, always ready to eat anything big and easily hunted, didn't help.
By the beginning of the Holocene (12,000ya) most camel species were extinct, and the others had been driven into small refuges. In southern Arabia, the dromedary survived only in the hilly fringes of the Rub al Khali, the Empty Quarter. The Bactrian, like Lama, took refuge in the mountains of Central Asia. And some scholars hold that a third species remained in the Atlas mountains of Morocco and Algeria until the introduction of the domestic camel. In any case, the precipitous climate and human-fueled decline of Camelllus is an apt analogy for the problems the animals face today.
Source: Wilson RT. 1984. The Camel. Essex: Longman Group.
Wednesday, November 5, 2008
American Lard
The twenty-first century will inevitably push the United States and India together. The two largest democracies on earth share an entrepreneurial spirit, strategic interests, and a massive immigrant community that twist together the nations' fates. Yet even in India, a nation that regularly elects ethnic and religious minorities as well as women to its highest ranks, there is a certain awe at the American ability for political self-renewal.
As with much of the world, much of this impression stems from the miracle of regular peaceful revolution. Every four (indeed, two) years, our government is opened to complete change. Yet the opposition doesn't withdraw from society or take to the hills with AK-47's, as they are liable to do even here. No-- what Americans might write off as bureaucratic weight, institutional inertia, or, at worst, conspiratorial class dominance is in fact our greatest asset: the rule of law.
But even in a country aligned against the United States until just the past decade there is the awareness that another, even greater trend is present in the periodic renewal of American democracy. The great names of Indian history tell a story of emerging nationhood, the gradual definition of identity in the face of British imperialism, Cold War socialism, and finally globalisation. The great names of American history-- Reagan, Kennedy, Roosevelt, etc.-- paint a much more complicated picture of generational change and constant rebirth.
The United States, almost uniquely, is a country without history. Or, more precisely, it is a country whose history does not define the present but instead reflects our hopes for the future. New ingredients might be thrown into the melting pot-- we're starting to see more chorizo and pho, plus some collards that were stuck on the rim-- but as you boil it pure fat will still rise to the surface. Our culture is rooted not in traditions of religion, caste, or family, but in the elusive sweetness of the all-American Lard (some might prefer the term Dream) we skim off the top. Hyperbole, perhaps, but it was American Lard that lubricated the peaceful transitions of the past 232 years of elections and American Lard that ran down expatraites' cheeks this morning.
And so we've chosen our 44th president. Forty years ago, in the same place where Obama made his victory speech, battle lines were drawn that would come to define a generation. Today, a new generation was defined just as clearly. But whereas the conflicts that divided the Baby Boomers centered around our culture and identity as Americans, the world that Generation O inherits is one requiring sacrifice and dedication. The financial, environmental, and political challenges facing us ensure that our lives, so far surely among the most privileged ever lived, will not be without struggle, nor without meaning.
I am reminded of a summer visit to the nation's capital, where after a stroll through Arlington National Cemetery my friend Noah and I walked across the Potomac to find a Lincoln Memorial mobbed by tourists, soldiers, and citizens. Yet even when filled with the chatter of schoolgroups and flashes of cellphone cameras, the sepulchral interior maintained the still reverence of the memorials across the river. Indeed, the very diversity who stood and contemplated Lincoln's legacy seemed to live out his words:
With malice toward none, with charity for all, with firmness in the right as God gives us to see the right, let us strive on to finish the work we are in, to bind up the nation's wounds, to care for him who shall have borne the battle and for his widow and his orphan, to do all which may achieve and cherish a just and lasting peace among ourselves and with all nations.
This will surely be the hardest Thanksgiving to spend away from home.
Monday, November 3, 2008
Roar Lion Roar
Thanks to the organizational prowess of the UPenn Alumni Association, Delhi Chapter I spent Halloween at the superposh Taj Hotel in the company of all sorts of Ivy League businessfolk, bluebloods, and brahmins. I came to Delhi for the weekend, intent on getting a dose of western nightlife after two months of early Bikaner nights, then sticking around to watch the election results roll in on CNN.